Guidelines for Management of Infants Delivered during the COVID-19 Pandemic in the USA and “Across the Pond”

Ahmed Afifi, MBBCH, MSc, David Corcoran MD, Allison C. Walker, MD, Alexandra Adamczak, M.D., T. Allen Merritt, MD, Jan Mazela, MD, PhD, Thomas A. Clarke, MD

The COVID-19 pandemic has brought unprecedented contemporary challenges to the delivery of health care to pregnant women and their infants. The World Health Organization (1), and the Centers for Disease Control and Prevention (2), and the American Academy of Pediatrics (3) have issued guidelines regarding mother-infant-postpartum care if a mother is COVID-19 positive and emphasize the importance of a model of shared decision making between mother, health care providers, and family members regarding the need for separation of mothers and infants while they are in the hospital. The guidelines from the American Academy of Pediatrics have been undergoing revision with the latest update provided on May 21, 2020. Key guidance focuses on the use of delayed-cord clamping and that “there is no reason why the infant should not have the benefits of delayed cord clamping and skin-to-skin contact after delivery.” The amended guidance acknowledges that “experts are divided” regarding rooming-in for mothers. “While difficult to separate mother and infant, this is the safest action, at least temporarily,” as they may provide the mother time to become less infectious,” and the goal is not to separate a family from its newborn.” The American Academy of Pediatrics strongly supports breastfeeding as “to date, breast milk is considered to be an unlikely course of transmission of SARSCoV-2 and encourages mothers who are COVID-19 positive to express breastmilk after appropriate hygiene which may be fed to the infant by an un-infected caregiver. If mothers prefer to nurse their infant, they should follow strict preventive precautions. Early hospital discharge is discouraged, and frequent post-discharge follow is recommended. Guidance for visitation to the NICU is that mothers and partners who are COVID-10 positive or persons under investigation should not enter the NICU until their status is resolved. (www.aapnews.org May 21, 2020).

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References:

  1. World Health Organization. (April 22, 2020) What matters to women in the postnatal period? http://www.who.int/news-room/detail/22-04-2020-what-matters-to-women-in-the-postnatal-period.
  2. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (April 4, 2020) Considerations for inpatient obstetric healthcare settings. https://cdc.gov/coronavirus/2019-ncov/hcp/inpatientobstetric-healthcare-guidance.html.
  3. Puopolo, KM, Hudak ML, Kimberlin DW, Cummings J. Initial Guidance: Management of Infants Born to Mothers with COVID-19: April 2, 2020, American Academy of Pediatrics
  4. Ma X, Zhu, J, Du, Uzhong. Neonatal Management During the Coronavirus Disease (COVID-19) Outbreak: The Chinese Experience. NeoReview May 2020 , 21(5) e293-2297.
  5. Ontario Health Toronto: Toronto Region COVID-19 Hospital Operations Table Version Date March 17, 2020, taken from Graham R. Covid-19 and he NICU Balancing Safety and Care. Neonatology Today, April 2020. 15(4): 25-28.
  6. Trevisanuto D, Moschino L, Doglioni N, Roehr, CC, Gervasi MT, Baraldi E. Neonatal Resuscitation Where the Mother Has a Suspected or Confirmed Novel Coronavirus (SARSCoV-2) Infection: Suggestion for a Pragmatic Action Plan. Neonatology April 24, 2020, DOI:10.1159/000507935.
  7. Ng, PC. Infection control measures for COVID-19 in labour suite and neonatal unit-A commentary Neonatology 2020 DOI:10.1159/000508002
  8. American Heart Association. Interim Guidance for Basic and Advanced Life Support in Children and Neonates with suspected or confirmed COVID-19. Pediatrics 2020 doi:10.1542/peds.2020-1403
  9. Zhu H, Wang L, Fang C, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCOV pneumonia. Transl. Pediatr. 2020; 9(1):51-60 dol: 10.21037/tp.2020.02.06
  10. Chen H. Guo J, Wang C et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 396(10226):809-815 dol:10.1016/S0140-673(20)30360-3.
  11. Royal College of Physicians and Surgeons, Ireland: Institute of Obstetricians and Gynaecologists of the Royal College of Physicians of Ireland outlined recommendations for Neonatal Management for Maternal and Neonatal Management, April 2020.
  12. Walker A. Royal Maternity Hospital Neonatal Unit COVID-19 Policy., Edition April 5 29, 2020. Belfast Health and Social Care Trust, Belfast, Northern Ireland
  13. Ziarnik M, Sosnowska J, Chmaj-Wierzhowska K, Figlerowicz M, Wysocki J, Mazela J. COVID-19 -epidemiologia, obraz kliniczyny oraz postepowanie z ciezarna I noworodkiem. Standary Medyczne Pediatria/April, 2020
  14. Zeng L, Xia S, Yuan W. et al. Neonatal Early-Onset infection with SARS-CoV-2 in 33 neonates born to mothers(https//www.statista.com/statistics/1043366/novel-coronavirsu2019nvov-cases-worldwidebycounty.html) rs with COVID-19 in Wuhan, China. JAMA Pediatr. March 26, 2020 (online) doi:10.1001/jamapediatrics.2020.0878.
  15. Breslin N, Baptiste C, Gyamfi-Bannerman C, Miller R. Martinez R, Bernstein K, Goffman D. COVID-19 infection among asymptomatic and symptomatic pregnant Women: Two weeks of confirmed presentation to an affiliated pair of New York City hospitals. American J. Obstet & Gynceol MFM. Advance online publication. Doi: 10.1016/ajogmf.2020.100118.
  16. Sutton D, Fuchs K, D’alton M, Goffman D. Universal screening for SARS-CoV-2 in Women Admitted for Delivery. N Engl J. Med 2020 382: 2163. Doi: 10.1056/NEJMc2009316.
  17. Campbell, KH, Tornatore JM, Lawrence et al. Prevalence of SARS-CoV-2 Among Patients Admitted for Childbirth in Southern Connecticut. JAMA May 26.2020. doi:10.1001/jama2020.8904.
  18. Munoz AC, Nawaratne U, McMann D, Ellsworth M, Meliones J, Boukas K. NEJM April 22, 2020: 382.e49 doi: 10.1056/NEJMc2020614.
  19. Liu W and Stovall S. Case of a preterm newborn with the nosocomial Acquisition of COVID 19 Infection in the Neonatal Intensive Care Unit and Contract Tracing. Neonatology Today 15(5) May 2020: 12-20.
  20. Buonsenso D, Costa S, Sanguinetti M et al. Neonatal Late COVID-19 Infection with Severe Acute Respiratory Syndrome Coronavirus 2. Am J Perinatology 2020 doi: 10.1055/s-9949-1710541.
  21. Note added in proof: On May 20, 2020, the Centers for Disease Control and Prevention Revised their recommendations on “Evaluation and Management Considerations for Neonates At Risk for COVID-19 and Care for Breastfeeding Women for the USA.

Disclosures: The authors do not have any disclosures.

The authors wish to acknowledge the special assistance of Thomas A. Clarke, MD, Retired Consultant, Rotunda Hospital, Dublin, Ireland, Co-Editor

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